Senior Analytical Scientist

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Senior Scientist to join our Analytical Sciences team, supporting our Manufacturing, Process Sciences (PS), and Quality Control (QC) functions in an on-site, laboratory-based role.

In this role, you will advance QC capabilities by developing robust, phase-appropriate, and lifecycle-managed analytical methods for novel modalities — including iSRNA/siRNA oligonucleotides and peptide therapeutics — while collaborating with Manufacturing, Process Sciences, Quality Control, and cross-functional CMC teams.

This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide. When & Where Location: Tempel Lane Travel: Occasional travel to support method transfer, vendor engagements, and program meetings Discover Your Role Develop and optimize analytical methods for product and raw materials, with a focus on iSRNA/siRNA and peptide modalities.

Design and review qualification and validation protocols so methods are stability-indicating and suitable for GMP release. Evaluate and implement new instrumentation and technologies in partnership with collaborators and vendors. Transfer control test procedures to QC, including training materials and acceptance criteria.

Troubleshoot method, process, and formulation issues, providing analytical support across functions. Lead OOS/OOT investigations and customer complaint assessments, driving data-driven root-cause conclusions. Communicate findings, risk, and mitigation strategies through technical reports and cross-functional meetings.

Mentor junior scientists and manage the full analytical method lifecycle, from development through retirement. This Role Might Be for You If You have hands-on experience developing and validating methods for oligonucleotide or peptide therapeutics.

You're comfortable working across LC-MS, CE, and other advanced analytical techniques to solve complex problems. You enjoy troubleshooting and leading investigations that require clear, data-driven reasoning. You communicate complex technical findings clearly to scientific and cross-functional audiences alike.

You take ownership of method lifecycle management and thrive in a fast-paced, science-driven environment. You're energized by mentoring others and shaping analytical strategy for novel modalities. This Role Requires BS/BA in Chemistry, Biochemistry, Biology, or a related field, with 6+ years of relevant industry experience in analytical development and QC method lifecycle.

Demonstrated experience developing and validating analytical methods for iSRNA/siRNA oligonucleotides and peptide therapeutics. Hands-on proficiency with LC-MS/MS, CE, ion-pair RP-HPLC, peptide mapping, and oligonucleotide characterization assays.

Proven track record of method transfer to QC, troubleshooting, and OOS/OOT investigations. Strong technical writing, data integrity practices, and presentation skills, with the ability to mentor and lead. Preferred Qualifications PhD in Chemistry, Biochemistry, or a related field.

Experience with hybridization-based assays and peptide mapping techniques. Experience applying DOE and statistical trending methodologies. Level for this position will be determined based on candidate qualifications. Does this sound like you?

Apply now to take your first step towards living the Regeneron Way! We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law.

Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship. Where necessary, we disclose salary ranges for roles in all countries in which we operate.

The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits.

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits.

For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/ . For other locations, additional information will be provided during the recruitment process.

If you have any questions, please speak with your recruiter. Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position. Salary Range (annually) $78,700.00 - $128,700.00